Improving Monitoring and Diagnosis for Process Control using Independent Component Analysis

Statistical Process Control (SPC) is the general field concerned with monitoring the operation and performance of systems. SPC consists of a collection of techniques for characterizing the operation of a system using a probability distribution consistent with the system\u27s inputs and outputs. Classical SPC monitors a single variable to characterize the operation of a single machine tool or process step using tools such as Shewart charts. The traditional approach works well for simple small to medium size processes. For more complex processes a number of multivariate SPC techniques have been developed in recent decades. These advanced methods suffer from several disadvantages compared to univariate techniques: they tend to be statistically less powerful, and they tend to complicate process diagnosis when a disturbance is detected. This research introduces a general method for simplifying multivariate process monitoring in such a manner as to allow the use of traditional SPC tools while facilitating process diagnosis. Latent variable representations of complex processes are developed which directly relate disturbances with process steps or segments. The method models disturbances in the process rather than the process itself. The basic tool used is Independent Component Analysis (ICA). The methodology is illustrated on the problem of monitoring Electrical Test (E-Test) data from a semiconductor manufacturing process. Development and production data from a working semiconductor plant are used to estimate a factor model that is then used to develop univariate control charts for particular types of process disturbances. Detection and false alarm rates for data with known disturbances are given. The charts correctly detect and classify all the disturbance cases with a very low false alarm rate. A secondary contribution is the introduction of a method for performing an ICA like analysis using possibilistic data instead of probabilistic data. This technique extends the general ICA framework to apply to a broader range of uncertainty types. Further development of this technique could lead to the capability to use extremely sparse data to estimate ICA process models

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit